Comparison of pharmaceutical films prepared from aqueous polymeric dispersions using the cast method and the spraying technique
Colloids and Surfaces. A, Physicochemical and Engineering Aspects
Mendoza-Romero, L ；Pinon-Segundo, E ；Nava-Arzaluz, MG ；Ganem-Quintanar, A ；Cordero-Sanchez, S ；Quintanar-Guerrero, D
This work focuses on: (i) the development of a device to form pharmaceutical films by a spraying technique. The principal idea is to simulate the film-coating operations; (ii) the investigation of some of the variables that influence the coating process (e.g., dispersion concentration, drying temperature and plasticizer presence) using Teflon plates and tablets as substrates: (iii) the evaluation of the quality of the films obtained by the spraying technique and the cast method. The results of this work showed a marked influence of the variables and the preparation method on the characteristics and quality of the films. Although the device proposed in this study does not reproduce all the factors involved in the coating process, it is a good tool to study and to predict film formation from latexes. (c) 2008 Elsevier BY. All rights reserved.
keywords:Spraying technique Casting method Film-forming process Minimum film formation temperature Latex dispersion SOLID DOSAGE FORMS MECHANICAL-PROPERTIES ETHYL CELLULOSE ACRYLIC LATICES DRUG-RELEASE LATEX WATER PLASTICIZERS SYSTEM TRANSMISSION
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